Iowa State Cyclones vs Purdue Boilermakers Prediction, Odds and Picks for Today, 12/06/25

It’s a top-10 battle as #1 Purdue welcomes #10 Iowa State in what should be an exciting matchup. The Boilermakers haven’t had too many problems this season — they knocked off then-#8 Alabama by 8 and cruised past then-#15 Texas Tech by 30 points. Purdue is ranked first in adjusted offensive efficiency according to KenPom and 19th in adjusted defensive efficiency. The Boilermakers have plenty of scoring options, with 4 players averaging double-digits — but this will be one of the hardest tests on the season for Purdue. Iowa State is more than capable of competing on both ends of the floor. 

Iowa State has faced only one ranked opponent this year, St. John’s, whom the Cyclones defeated 83-82 in the Players Era Tournament. The Cyclones have to be eager to prove to the college basketball world that they have the talent to take down #1 Purdue. Leading this Iowa State offense is Joshua Jefferson, who is averaging 18.4 and 7.3 rebounds per game. The Cyclones have 4 players averaging double-digits, and 3 of those 4 players are averaging at least 18 points per game. This will be an exciting matchup, and even though the Cyclones haven’t faced a defense like Purdue yet this season, they have enough talent to keep this game close. Look for Iowa State to push the pace against Purdue and keep this game closer than the Boilermakers would like. 

Iowa State vs Purdue prediction: Iowa State +5 (-110) available at time of publishing. Playable at that number.

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