Jackson State Tigers vs Louisville Cardinals Prediction, Odds and Picks for Today, 11/06/25

This is a general principle pick, if there ever was one. The Ville is an ACC dynamo, while the Tigers are a team that comes from arguably the weakest division in college hoops – the SWAC. Let’s go back to last year. J-State was winless out of the chute in non-conference play, only to make things interesting once they got into conference play. But that’s an afterthought here. What the market sees is that the Tigers were doubled up by #17 Illinois in their season opener, in which they gave up 110-plus points. Now, the prognosis seems worse against the #11 team in the country.

What does this do? Make the Cards prone to an overlay. We’re not going to go much further than the fact that these 2 teams are on opposite ends of the spectrum in terms of perceived quality and the price is reflected in that. However, whether Louisville runs the Tigers out of the gym or not, this is a big cushion of points that the Tigers can easily come in under if at any point UL takes their foot off the gas.

Jackson State vs. Louisville prediction: Jackson State Tigers +35.5 (-110), available at time of writing. Playable to +35.

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