Kentucky Wildcats vs Iowa State Cyclones Prediction, Odds and Picks for Tomorrow, 03/22/26

Kentucky came into March with the appearance of a team that is more brand name than substance, and depending on how one interpret events of Friday that may be the market’s position here again. That makes them a far less marketable option compared to Iowa State who looks every bit the contender to cut down the nets many regard them as. Thats where we start.

On Friday, ISU cruised past Tennessee State. Big Blue needed theatrics against Santa Clara. In what was one of the wildest finishes in tournament history, Kentucky escaped with an overtime win and covered as a 3.5-point choice despite being placed on upset alert by many before tip-off. The Cats were just seconds away from suffering an early exit until a miracle half-court shot gave them second life. Immediately, many will say that theatrics might work against a WCC team like the Broncos, but not against a stud like the Cyclones. The price however suggests that UK has an honest chance to cause more chaos. And they do have a chance here. Kentucky was big on defense when it needed to be and made the plays it had to when required to get the job done. Thats the DNA of a team that can make a deep run and excel on the big stage contrary to popular opinion. The line suggests that the Cats make more noise. I am taking them to advance. Kentucky outright.

Kentucky vs Iowa State prediction: Kentucky +175 (ML) available at time of writing. Playable to the number.