Louisville Cardinals vs Clemson Tigers Prediction, Odds and Picks for Today, 02/28/26

Louisville is laying a short tag on the road to unranked Clemson. That is exactly the kind of line that invites money on the ranked side while quietly signaling volatility. Clemson has been excellent at home (11–3 SU) while Louisville’s profile flips away from home (3–6 SU). That’s why this number appears short.

Clemson’s advantage here is not just where the game is played, but also how they play the game too. The Tigers defense and physicality tend to control pace and shot quality, turning games into contests where each empty trip matters more than raw scoring talent. That’s a big problem for The Ville. When Clemson is at home, road teams that aren’t consistently sharp away on the highway get punished, not necessarily with blowouts, but with two or three key sequences that decide the night. The posted price is a warning that this could be Louisville’s future. I’m listening. Tigers outright.

Louisville vs Clemson prediction: Clemson +101 (ML )available at time of publishing. Playable to the number.