Michigan State Spartans vs East Carolina Pirates Prediction, Odds and Picks for Today, 11/25/25

Michigan State has already picked up 2 wins over top-25 opponents this season and will look to remain unbeaten as it opens the Fort Myers Tip-Off Tournament against East Carolina. The Pirates haven’t had as much success as the Spartans to open the season, dropping 2 in a row and now facing their toughest opponent of the year. According to KenPom, Michigan State ranks eighth nationally in adjusted defensive efficiency, while East Carolina sits at 278th in adjusted offensive efficiency — a major mismatch that could make scoring difficult for the Pirates.  

The Spartans are shooting 45.4% from the field and averaging 79 points per game, with 4 players scoring in double-figures. While Michigan State may not be the most explosive offensive team, it consistently wears opponents down with elite defense. The Pirates average 72 points per game, and they simply don’t have the same depth as the Spartans to keep up in this matchup. Defensively, the Pirates are allowing opponents to shoot 45.7% from the floor and averaging 81.6 points per game. Michigan State should be able to control the pace from the opening tip and make life difficult for the Pirates throughout the entire game. Look for the Spartans to get the job done and win big, making them my best bet of the day. 

Michigan State vs East Carolina prediction: MSU -22.5 (-110) available at time of publishing. Playable at that number.

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