Nebraska Cornhuskers vs Illinois Fighting Illini Prediction, Odds and Picks for Today, 12/13/25

We have two ranked Big Ten Conference teams set to square off on Saturday afternoon as No. 23 Nebraska heads to State Farm Center to take on No. 13 Illinois. Nebraska is coming off a dominating 30-point victory over Wisconsin, shooting 54.1% from the floor. Rienk Mast led the team with 17 points, but this Cornhuskers team has a well-balanced attack that could keep Illinois on its heels early.

Illinois, however, brings a lot of offensive firepower that will keep Nebraska busy. They have five players averaging double digits and leading the Fighting Illini this season is Kylan Boswell with 15.7 points and 4.4 rebounds per game. According to KenPom, Illinois is ranked 5th in Adjusted Offensive Efficiency and Nebraska is ranked 46th. This Illinois team has a ton of depth, plenty of players who can rebound, and they don’t typically turn the ball over a lot. Illinois is 2-2 against top-25 opponents this year, and this is Nebraska’s first actual big test on the road while taking on a top-25 team. Nebraska may be able to hang around early on, but I think Illinois pulls away late in the second half.

Nebraska vs Illinois prediction: Illinois -10.5 (-110) available at time of publishing. Playable at that number.