Oklahoma State Cowboys vs Arizona Wildcats Prediction, Odds and Picks for Today, 02/07/26

The Oklahoma State Cowboys (16-6, 4-5 Big 12) travel to Tucson on Saturday to face the No. 1 Arizona Wildcats (22-0, 9-0 Big 12) at McKale Center in a matchup that heavily favors the home team. Arizona enters undefeated at 22-0, the best start in program history, and sits atop both the AP and Coaches Polls, tied for the longest No. 1 streak in school history. The Wildcats have won all 22 games by an average of 21.0 points and rank No. 1 in the NCAA NET Rankings, including a perfect record against Quad 1 opponents. Arizona boasts elite balance and efficiency, ranking among national leaders in scoring offense (89.5 PPG), rebounding margin (+13.0), field goal percentage (.516), and fastbreak points (17.9), while holding opponents to 68.5 PPG on 39.4% shooting. Offensively, Arizona is loaded with contributors, including Brayden Burries (15.3 PPG), Koa Peat (14.8 PPG), Jaden Bradley (13.9 PPG, 4.5 APG), and 7-foot-2 Motiejus Krivas (11.0 PPG, 8.3 RPG).

Oklahoma State has been strong on the offensive end, averaging 86.5 points per game this season and coming off recent conference wins over Utah and BYU, including a 30-point performance from Anthony Roy in the BYU victory. The Cowboys prefer an up tempo style and are at their best when games turn into shootouts, but defensively they allow approximately 80.4 points per game, a concern against Arizona’s explosive attack. Oklahoma State has never beaten Arizona and will be making its first ever trip to McKale Center, where Arizona is 72-6 under head coach Tommy Lloyd, one of the nation’s most dominant home court marks. Given Arizona’s depth, pace, rebounding edge, and ability to overwhelm opponents early, the Wildcats are positioned to control this matchup from the opening tip. With the spread set at -20.5, Arizona’s consistent blowout profile and Oklahoma State’s defensive limitations point toward a convincing home win.

Oklahoma St vs Arizona Prediction: Arizona -20.5 (-110) available at time of publishing. Playable to -22