Oklahoma State Cowboys vs Oklahoma Sooners Prediction, Odds and Picks for Today, 12/13/25

This line tells a story, and it’s one worth listening to. On the surface, it looks like an easy case for Oklahoma State: undefeated, catching points, in a rivalry game, against an Oklahoma team that just got smacked by double digits at Arizona State. That’s exactly the profile the market loves to chase. And for a brief moment, they did — the number pushed as high as Sooners -3.5 before the market stepped in and dragged it back down.

That move matters. In a game expected to be tight, grabbing the better of the number is everything. Yes, Oklahoma State is undefeated, but that record is doing a lot of the heavy lifting in perception. Meanwhile, Oklahoma’s recent loss is doing the opposite — suppressing their price. That’s the key point: despite the public-facing reasons to back Oklahoma State, the Sooners are still favored. That’s not an accident. If this were purely about records or momentum, Oklahoma would be the underdog. Instead, the market continues to lean their way, which is pivotal. This is one of those spots where the instinctive play feels obvious — and is usually wrong. We don’t need Oklahoma to dominate. We just need them to win close at home where they are undefeated to get home. This is essentially a pick-em and given the fact that the Pokes have yet to play on the road this season, that’s fine by us.

Oklahoma State vs Oklahoma prediction: Oklahoma -2 (-110) available at time of publishing. Playable to the number.