Saint Louis Billikens vs Loyola-Chicago Ramblers Prediction, Odds and Picks for Today, 02/13/26

The No. 18 Saint Louis Billikens (23-1, 11-0 A-10) head to Gentile Arena riding a 17-game winning streak to face the Loyola-Chicago Ramblers (6-19, 2-10 A-10) in a matchup that heavily favors the conference leaders. Saint Louis has been dominant on both ends of the floor, leading the NCAA in scoring differential while holding opponents to approximately 67.7 points per game and just 36.4% shooting from the field. Offensively, the Billikens stretch defenses with 11.4 3-pointers per game, fueling a balanced attack led by Robbie Avila (12.8 PPG). They are coming off an 82-58 win over La Salle and remain a perfect 7-0 on the road, underscoring their ability to dictate tempo and execute efficiently away from home.

Loyola-Chicago, meanwhile, has endured a difficult campaign at 6-19 overall — struggling on both ends and being outscored by roughly 10 points per game. The Ramblers allow about 77.6 points per contest while opponents have shot around 42.2% from the field, and consistent scoring has been hard to come by in A-10 play. While Loyola has occasionally kept games competitive and even pulled an upset in this matchup last season, the current form and efficiency gap between these programs is significant. Saint Louis’ perimeter shooting, defensive discipline, and depth give the team multiple ways to build and extend a lead — especially against a defense that has shown lapses throughout conference play. Given the Billikens’ dominant metrics, road success and sustained momentum, this shapes up as a game they can control from start to finish.

Saint Louis vs Loyola Chicago prediction: St. Louis -18.5 (-110) available at time of publishing. Playable at that number.

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