Syracuse Orange vs Duke Blue Devils Prediction, Odds and Picks for Today, 02/16/26

After a dominating win over No. 24 Clemson on Saturday, No. 4 Duke will look to keep things rolling when they host Syracuse on Monday night. The Blue Devils pulled away in the second half against the Tigers, shooting 42.6% from the floor and outrebounding them 37-32. Syracuse is also coming off a big win of their own, defeating SMU 79-78 on Saturday while shooting 45% from the floor. With only a few weeks left in the regular season, the Orange will do everything possible to try to move up in the ACC standings. 

Duke has been terrific all season, and a big part of that success is Cameron Boozer, who is averaging 22.8 points and 9.9 rebounds per game. Syracuse’s leading scorer, Donnie Freeman, is averaging 17.6 points and 7.2 rebounds per game, and the Orange have three additional players scoring in double figures. That balance could help them test Duke’s defense and get things going offensively, and not have to rely just on Freeman to carry the team. Defensively, Duke leads the ACC in defense this season with 63.1 points per game against conference opponents, where Syracuse ranks 9th with 72.2 points per game. The Orange are 2-4 on the road this season, but they’ve competed well against strong opponents. They defeated then-No. 13 Tennessee by two earlier this season, lost to Clemson by three, lost to then-No. 14 UNC by 10, and then-No. 18 Virginia by 13. Duke is going to win this game, but I think Syracuse has enough talent offensively and defensively to keep this game from getting out of hand. 

Syracuse vs Duke prediction: Syracuse +19.5 (-115) available at time of publishing. Playable at that number.

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