Villanova Wildcats vs La Salle Explorers Prediction, Odds and Picks for Today, 11/19/25

Some may not realize that the Villanova Wildcats and La Salle Explorers are rivals. The Wildcats have been to the pinnacle of the college basketball mountaintop, while La Salle hasn’t won a conference title in 30 years. However, La Salle did cut down the nets in 1954 — but that was long before March Madness was a thing. The point I’m trying to make is that the knee-jerk reaction is to back the Wildcats. ‘Nova has the more brand recognition and public appeal; the Explorers do not.

But, as mentioned, this is a rivalry — one with Philadelphia roots. These teams are cross-town enemies. The Explorers have not beaten the Wildcats in more than 12 years; it has been 9 straight for ‘Nova. In a packed-out Glaser Center with a squad that has nothing to lose in this contest, thus all the more inclined to throw the kitchen sink at the visitor, the Explorers plus the points makes the most sense. This, after all, is Villanova’s first true road game this season and it is stepping into a Hornet’s Nest against a rival that will have nothing to lose. Laying the points here is too risky.

Villanova vs La Salle prediction: La Salle +11.5 (-110) available at time of publishing. Playable to +11.

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