Western Carolina Catamounts vs Duke Blue Devils Prediction, Odds and Picks for Today, 11/08/25

The Western Carolina Catamounts will head to Cameron Indoor Stadium as they get ready to take on No. 6 Duke in hopes to pull off an upset. Duke enters this matchup at 1-0 with a 75-60 win over Texas on Tuesday night. Duke is eager to clean up their problems against Western Carolina, and they should have no issues in doing so. The Blue Devils will lean towards the sophomore Isaiah Evans to help carry his team and move to 2-0 on the season. 

Western Carolina struggled against Cincinnati in their last start, losing 94-63, and I don’t expect much of a difference in this matchup. The Blue Devils are way more talented than Cincinnati, and despite them scoring only 75 points against Texas, they should be able to run up the score in this matchup. I expect the freshman Cameron Boozer to step it up in this matchup, and the Blue Devils have the depth on their roster to exhaust every move Western Carolina makes. Look for Duke to coast in this one and win big, making them my best bet of the day. 

Western Carolina vs Duke prediction: Duke -35 (-110) available at time of publishing. Playable at that number.