College Football Best Bets

Here you will find our college football best bets for every week of the 2025-26 season. Our cappers have a wealth of experience and expertise in college football bets, data analytics and statistical modelling, to bring you the best NCAAF bets all season long.

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8:00 PM ET
Today
Houston Cougars
UCF Knights
Houston
UCF
Point Spread PickBest Bet
Houston -1.0(-110)

Friday’s weekly Big 12 special takes us to Florida for a battle between the Houston Cougars and the UCF Golden Knights. Friday night games are crazy and unpredictable, but in this case, I think one team is far better than the other. Both are looking to rebound from losses last week. UCF lost to Baylor, 30-3, in a game that the Knights were awful. That marked their 4th conference loss, with their only victory coming at home against West Virginia. Coincidentally, that is who beat Houston last week in a surprise upset. The Cougars were upended by the Mountaineers, a painful second conference loss that likely will ruin any hopes of a sneaky conference championship appearance. Given those results, Houston is only a narrow favorite on the road here. I am happy to hammer the heck out of that, as the Cougs are the far better team. Give me Houston -1.

The problem for Houston last week was that they turned the ball over 4 times. Nobody should expect to win like that, and especially not a team that is mostly just average offensively. But the sneaky thing here is that the Houston offense has really been developing lately as Conner Weigman has gotten more comfortable. The UCF defense is a solid unit, ranking 20th in the nation overall in total yardage allowed, but they still gave up over 400 yards and 30 points to Baylor last week, and Baylor had a big lead early and mostly took their foot off the gas. More concerning is the Knights’ offense, which looked bland, vanilla, predictable, and ineffective last week. And that was against a terrible Baylor defense; the Houston defense is much more formidable. I just don’t see this game going the way of the Knights, even at home on a Friday night.

Houston vs UCF Prediction: Houston -1 (-110) available at the time of publication. Playable to -2.5.

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9:00 PM ET
Today
Tulane Green Wave
Memphis Tigers
Tulane
Memphis
Point Spread PickBest Bet
Memphis -4.5(-110)

A massive game in the AAC headline’s Friday night’s action when the Tulane Green Wave travel to Memphis to play the Tigers. Tulane enters this contest fresh off an ugly loss at UTSA in which the Green Wave turned the ball over 4 times, including 2 Jake Retzlaff interceptions, a Brendan Sullivan interception, and a fumble lost by RB Javin Gordon. The loss firmly removes Tulane from the College Football Playoff picture if it wasn’t already, but the Green Wave are still 3-1 in the AAC with a real chance to play for a conference championship with a win in Memphis on Friday night. 

Speaking of the CFP, Memphis sits at 8-1 with a renewed chance to be the postseason Group of 5 representative thanks to its comeback win over USF a couple weeks ago. The Tigers followed that performance up by taking care of business at Rice last week, easily covering the 14-point spread while holding the Owls to 212 total yards. QB Brendon Lewis left the game late to a lower-body injury, and his status is technically in question for this game. Though, we heard that leading up to the USF game, in which he ended up playing. Considering he practiced on Monday, expect Lewis to be a full-go here again.

Interestingly enough, Tulane is taking some money as I write this on Tuesday evening, which is a move I disagree with. First, this will be the 2nd game of a back-to-back road trip for Tulane, and playing on the road hasn’t been all that kind to the Green Wave this year despite coach Jon Sumrall’s prior success against the number as a visitor. For reference, Tulane is just 1-3 ATS on the road this year. Conversely, Memphis has been a money machine this year, currently 8-1 SU and ATS including home wins over the aforementioned Bulls and the Arkansas Razorbacks of the SEC. In fact, the Tigers have been impossible to beat at home since the start of last year. 

Obviously playing at home is advantageous, but playing clean football is also advantageous – and that’s exactly what Memphis has done of late. The Tigers have just 1 turnover in their last 3 games, bolstering their top-10 turnover margin. They’ve also been relatively clean from a penalty perspective, sitting top-50 in penalties per game. Meanwhile, the Green Wave are 116th in penalties per game, and though Retzlaff has thrown just 3 picks this year, he has 8 turnover-worthy plays in his last 4 games – and it finally caught up to him last week when he was benched in the blowout loss to UTSA. Given the fact that Memphis is top-30 in havoc generated by defensive backs over the last 5 weeks, Retzlaff could be in for another turnover-filled day. 

Perhaps the biggest advantage for Memphis in this game is in the red zone. The Tigers reach the red zone at a top-20 rate and boast the 3rd-best scoring percentage in the country, which includes both touchdowns and field goals. When you cut that down to just touchdowns, the Tigers are #1, finding the end zone on 82% of their red zone trips. Tulane, on the other hand, has found pay dirt on just 50% of red zone trips. Defensively, it’s much of the same. The Tigers surrender points on 75% of opposing red zone trips, while the Green Wave yield points on over 86% of those possessions. 

Expecting Lewis to play, I make Memphis over a touchdown favorite at home against Tulane. Look for the Tigers to excel in red zone situations, play clean football, and make use of their more efficient and explosive rushing attack in a win and cover at home. For what it’s worth, if the opportunity presented itself, the Tigers would probably want to run the score up to make their CFP resume look better; just something to consider. 

Tulane vs Memphis prediction: Memphis Tigers -4.5 (-110) at the time of publishing. Playable to -7. 

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1:00 PM ET
Tomorrow
Ohio State Buckeyes
Purdue Boilermakers
Ohio State
Purdue
Point Spread PickBest Bet
Ohio State -30.0(-110)

The Ohio State Buckeyes hit the road for West Lafayette to battle the lowly Purdue Boilermakers. The No. 1-ranked Buckeyes rolled the Penn State Nittany Lions last week, and they have scored 34 or more points in each of the past 4 games, while going 7-0-1 ATS this season. The defense allowed 14 points in the first 2 quarters last week against the Nittany Lions, but the D has still allowed just 55 points through 8 games, or 6.9 points per game. Against Purdue, Ohio State rolled to a 45-0 win on November 9, 2024 last season in Columbus, covering a 37-point mark. The Buckeyes are 3-0 ATS in the past 2 meetings, covering spreads of 17 or more points. Ohio State has scored 41 or more points in 4 of the past 5 tries against Penn State, and the winning team has scored at least 41 points in each of the past 5 in the series.

For Purdue, the Boilermakers are 2-7 SU and 3-5-1 ATS. While the Boilermakers did put up a fight, falling just 21-16 last week at Michigan as a 21-point underdog, the offense continues to struggle to cobble together any points. The defense hasn’t really been trampled in the past 4 games, but that’s also against Michigan, Rutgers, Northwestern and Minnesota. In 3 straight games against USC, Notre Dame and Illinois, the Boilermakers allowed 132 total points, or 44.0 PPG, including 99 combined points against the Illini and Irish. QB Julian Sayin, WR Jeremiah Smith and the Buckeyes should roll the Boilermakers.

Ohio State vs Purdue prediction: Ohio State Buckeyes -30 (-110) at time of publishing. Playable to -33.5.

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1:00 PM ET
Tomorrow
The Citadel Bulldogs
Ole Miss Rebels
The Citadel
Ole Miss
Point Spread PickBest Bet
The Citadel +54.5(-110)

This one isn’t rocket science. You’re getting an FCS tune-up opponent catching nearly 55 points, and at this stage of the season, that’s more of a strategic grab than anything else. The Citadel is stepping into a paycheck game, yes, but Ole Miss has zero incentive to turn this into a track meet. The Rebels have bigger fish to fry.

Next week, Florida comes to Oxford — and say what you want about the Gators, but they haven’t quit on their season, and they might even be playing better under Billy Gonzales right now. After Florida, Ole Miss hits a bye, then a rivalry date in Starkville with Mississippi State. Lane Kiffin knows what’s in front of him. This program is sniffing a 1-loss finish, maybe even a top-5 résumé in the CFP poll. Nobody here is interested in risking starters or flexing style points on The Citadel.

Expect Ole Miss to get out to a comfortable lead and immediately shift into “stay healthy, get reps, don’t show anything” mode. Starters get pulled, backups run the offense, and the clock becomes the Rebels’ friend. If The Citadel sneaks in even 1 or 2 touchdowns — and Ole Miss’ defense has certainly given up scores to lesser opponents this year — now you’re asking the Rebs to push 60 to cover. They won’t. Grab the points.

The Citadel vs Ole Miss prediction: The Citadel Bulldogs +54.5 (-110) available at time of publishing. Playable to +54.

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3:00 PM ET
Tomorrow
Nebraska Cornhuskers
UCLA Bruins
Nebraska
UCLA
Money Line PickBest Bet
Nebraska Win(+105)

Saturday night will feature a matchup between the UCLA Bruins and the Nebraska Cornhuskers. After starting the season 0-4, UCLA forced itself back into relevancy with 3 straight conference wins. The winning streak ended last week abruptly when the Bruins lost 56-6 against undefeated Indiana. Quarterback Nico Iamaleava could not avoid turnovers against Indiana. He finished the game completing less than 50% of his passes and with 2 interceptions. Iamaleava has now thrown only 1 touchdown and 4 interceptions in his last 2 games. The Bruins will try to bounce back against 6-3 Nebraska. Nebraska lost a heartbreaker last weekend against USC, 21-17. The Cornhuskers led 14-6 in the second half, but they could not stop USC’s comeback effort. Quarterback Dylan Raiola had a subpar outing, only throwing for 91 yards — his lowest total of the season. 

It seems UCLA’s winning ways after firing head coach DeShaun Foster in the middle of the season have come to an end. They once again looked like the team that started the season that lost their first 4 games by an average of 17 points. Iamaleava has been inconsistent this season, but he has the potential to be a future NFL quarterback. Unfortunately for Iamaleava, he will be going up against the second-ranked defense in the FBS against the pass. Nebraska allows only 128.3 yards passing per game, and we saw how dominant it can be last week against an excellent USC offense. The ‘Huskers held USC quarterback Jayden Maiava to 135 yards passing and 1 interception. Maiava completed just 9 of 23 passes throughout the game. UCLA’s offense relies heavily on Iamaleava; he leads the team in both rushing and passing. Nebraska has a good opportunity to bounce back from its poor offensive performance last week, especially on the ground. UCLA’s defense ranks 124th in FBS in rushing yards allowed at 195 yards per game. Nebraska’s running back room is led by junior Emmett Johnson, who has already run for 1002 yards this season and 10 touchdowns. If Johnson can get the running game started, passing lanes should open up later for Raiola.

Nebraska vs UCLA prediction: Nebraska ML (+105) available at time of publishing. Playable at that number.

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NCAAF Best Bets
40.9%
Win %
18Wins
26Losses
0Pushes
Percentage only includes Wins and Losses

What Are Our College Football Best Bets

At Pickswise our team of expert college football handicappers conducts extensive research across all of the best college football action throughout the season and into the postseason, with the sole aim of bringing you the most informed and best free college football bets around. 

Alongside our expert analysis, our handicappers will post their prediction for every game including picks on the over/under market, Against the Spread, and Moneyline picks. Each of our selections across Pickswise is given a confidence rating ranging from 1 to 3 stars, with 3 stars being the most confident, and 1 the least.

In addition to our confidence ratings, college football bettors in particular – with the sheer number of games each weekend, like to know what our most confident selections are across the slate. This is where our College Football Best Bets page comes to the fore, here we detail just that, our most confident selections, our NCAAF best bets this weekend.

College Football Best Bets Today

Find all of our best college football bets today, right here on our College Football Best Bets page.

There are countless ways in which you can wager on a college football game and with hundreds of games each week in a typical season, being selective in your wagering is arguably the most important aspect in achieving long-term betting success on college ball.

Covering every game in the required detail is a long process, and then filtering down your picks into those top selections, your best bets is a difficult task. Fortunately, here at Pickswise, we lean on industry-leading analysis and decades of wagering experience to bring you the top NCAAF best bets this week for free. Not only do we break down every match, but we also highlight our best college football bets today right here, each week, so be sure to check back for those best bets across the college football slate. 

The College Football Best Bets page works perfectly with our College Football Predictions page where you can find all of our game previews, in addition to our best bets here, to combine for a comprehensive view of today’s college football games.

What Is The Best Site To Wager On Your College Football Best Bets Today

There are many ways in which you can wager on our college football best bets today, with all major sportsbooks all vying to offer the most competitive odds. As with any sports wagering you do, you must compare odds and markets to seek out the best value with all of our NCAAF best bets.

With all of our College Football Picks, and College Football Parlays, we post the best odds, and the sportsbook offers those odds next to our selections.

With the volatility of sports odds, these can change quickly, so be sure to check before you wager. An extra point on the spread can be the difference between winning and losing, and why bet the money line at +250 when you can get +350 elsewhere? 

Unsure where is best to place your college football best bets? Or looking to make the most of new account offers and promo codes? Be sure to check out our Online Sportsbook Reviews for the lowdown on all of the top online sportsbooks in your state, and find the best promo codes on our Bonuses Page.

Best College Football Bets This Weekend

With so many college football games scheduled across the conferences each weekend, you simply can’t bet on them all. Our college football best bets this weekend are just that, our best bets across this weekend’s college football games.

All of our best bets are posted during the week to allow you to take in and break down our analysis and best bets, before deciding whether you agree, and want to place a bet.

Posting our best college football bets ahead of time for this weekend also gives you more time to shop the odds, and in all likelihood, ensure you get the best odds, on our best bets. 

Best Bets Against The Spread College Football

The most popular college football bet is betting against the spread (ATS). Against the spread betting isn’t about picking a winner of the game, it’s about picking the team who will cover the spread, a line set by sportsbooks. Let’s say you bet your money that Team A covers the spread (wins by a certain amount of points), Michigan -8.5 for example. Or that Team B will cover the spread (keep the game closer than oddsmakers expect), Penn State +8.5. If Michigan beat Penn State 30-27, then Penn State covers the spread, and underdog backers are cashing tickets with +8.5 on Penn State. Whereas if Michigan wins 30-20, more than 8.5 they cover the spread and favorite backers are cashing tickets. 

When Do You Post Your NCAAF Best Bets For This Weekend 

We post all of our NCAAF Best Bets at least a day before the scheduled college football match. We wait until this point to allow our expert handicappers to consider every angle such as injury updates, press conferences and team news, as well as extensive statistical research. Our NCAAF Best Bets are exactly what they say on the tin. With so many NCAAF games played each weekend, we have a confidence rating on all of our NCAAF Picks, with 3 stars being the most confident, and then we further narrow down our three-star plays into our NCAAF Best Bets. These will typically be posted on a Thursday or Friday ahead of the weekend’s schedules. Check out this week’s NCAAF Best Bets right here on the College Football Best Bets page.

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