College Football Picks

Get free college football picks for the best action throughout 2025-26 season, including college football picks against the spread, straight-up, money line picks, and total picks (over/under). Our data-devouring experts find you the best betting trends and NCAAF picks this week.

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7:30 PM ET
Thu Sep 18
ESPN
Rice Owls
Charlotte 49ers
Rice
Charlotte
Point Spread Pick
Rice -3.5(-110)

The Rice Owls hit the road for Jerry Richardson Stadium in the Queen City to take on the Charlotte 49ers in an American Conference matchup. The Owls opened the season with a 14-12 win on the road against Louisiana as a 10-point underdog. While they’re 0-2 against the spread in the past 2 games, Rice lost a tough 35-9 battle against crosstown rival Houston before bouncing back with a 38-17 win over Prairie View A&M at home. Regardless of their ATS record, the Owls are playing with a lot of confidence, and they have a respectable defense, unlike the 49ers right now.

The 49ers scored a 42-35 win over Monmonth of the FCS. While a victory is nice, Charlotte allowed an FCS quarterback to throw for 410 yards. Monmouth totaled 458 yards and 28 first downs against Charlotte, too, having their way in the stadium of the 49ers. Charlotte was also sloppy, turning it over three times, while forcing zero turnovers. If the 49ers play like that against the Owls, they’re going to get their doors blown off. Charlotte is 0-2 straight up and ATS in 2 games against FBS opponents, averaging just 7 points per game, while allowing 27 points on the other side. Expect more of the same on Thursday.

Rice vs Charlotte prediction: Rice -3.5 (-110) available at time of publishing. Playable to -5.5.

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Joe Williams
12:00 PM ET
Sat Sep 20
ESPN2
Point Spread Pick
TCU -6.5(-115)

The final chapter of the Battle for the Iron Skillet takes place on Saturday afternoon from Amon G. Carter Stadium on the campus of TCU. The rivalry between the Mustangs and the Horned Frogs is a storied one, dating back to 1915, but this will be the last time they meet on the gridiron for the foreseeable future due to conference realignment and changes in scheduling. SMU has taken three of the last five meetings, but TCU has controlled this series since the mid-1990s. The Horned Frogs are also in a revenge spot here, as the Mustangs took advantage of 5 TCU turnovers and 14 TCU penalties in a 66-42 win at SMU last year. 

The Mustangs benefitted from 3 defensive/special teams touchdowns in the win against the Horned Frogs last year, not to mention SMU running back Brashard Smith’s 127 yards and 3 touchdowns on 18 carries. Unfortunately for the Mustangs, Smith is now with the Kansas City Chiefs, and the defense lost most of its starters from a season ago. Given the roster change, I have a tough time seeing the Mustangs replicating that defensive performance on the road against a TCU team that is 7th nationally in turnover margin through 3 weeks. In fact, the penalty misfortunes in this matchup may now rest with the Mustangs, who are currently 125th in penalties per FBS game.

While the travel is minimal from SMU to TCU, this will be the second straight true road game for the Mustangs, and the atmosphere in a sold-out Amon G. Carter Stadium will be the most hostile SMU has seen this season. That’s not exactly reassuring for the Mustang offense, led by a quarterback in Keving Jennings who already has 8 turnover-worthy plays in 3 games – 2 of which came against an FCS opponent. Even with a great offensive line in front of him, I struggle to trust him in a road setting, especially against a TCU defense that has succeeded in generating havoc thus far.

TCU’s offense is going to be difficult to keep up with if SMU can’t protect the ball. For reference, the Horned Frogs are 6th nationally in PPA per play and 5th in yards per play, in addition to being much better than the Musangs at finishing drives with points. Give me the Horned Frogs to win and cover at home.

SMU vs TCU prediction: TCU Horned Frogs -6.5 (-115) at the time of publishing. Playable to -7 (-120).

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Sam Avellone
7:30 PM ET
Fri Sep 19
ESPN
Tulsa Golden Hurricane
Oklahoma State Cowboys
Tulsa
Oklahoma State
Point Spread Pick
Tulsa +13.0(-110)

The Tulsa Golden Hurricane hit the road to battle the Oklahoma State Cowboys at Boone Pickens Stadium in Stillwater. Oklahoma State leads the all-time series 44-28-5, including 10 straight victories in the series since Sept. 11, 1999, including a 45-10 win last season on Sept. 14 in Tulsa. Oklahoma State is 6-1 against the spread in the past 7 meetings, with the under going 4-0.

Tulsa dropped a 42-23 game at home against Navy, failing to cover as a 14-point underdog as the over cashed. The under is 2-1 in 3 games to date, however. For Oklahoma State, the last time we saw it on the football field, it was blasted 69-3 at Oregon as a 28.5-point underdog. Oklahoma State will be champing at the bit to get back on the field after a bye win Week 3. However, Oklahoma State is 0-2 against the spread so far this season, and it’s hard to understand why the Cowboys are favored by 2 touchdowns in this one. The Golden Hurricane might not win, but a team which was dusted by 66 last time out has no business laying double digits to anybody. Take the Golden Hurricane plus the points in this one.

Tulsa vs Oklahoma State prediction: Tulsa +13 (-110) available at time of publishing. Playable to +12.5.

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Joe Williams
7:30 PM ET
Sat Sep 20
NBC
Illinois Fighting Illini
Indiana Hoosiers
Illinois
Indiana
Point Spread Pick
Indiana -4.0(-110)

One of the biggest games on the Week 4 college football slate comes in Bloomington, Indiana on Saturday, when the Illinois Fighting Illini take on the Indiana Hoosiers. This is a massive game in the Big Ten for a couple of teams that have an outside shot of disrupting the College Football Playoff picture, and it features a team that I am looking to back against a team I feel very comfortable fading.

Earlier this season, I faded Illinois against Duke and I would still make that bet again given the circumstances around that game. After all, Illinois won the turnover battle 5-0, was gifted points by the Blue Devils on numerous occasions and was able to take advantage of special teams miscues and untimely penalties from Duke in the victory. The Illini were still outgained in that game and Duke registered a 49% success rate (85th percentile) on an Illinois defense that is outside the top 100 in passing success rate and rate of quality drives allowed (CFB-Graphs). In steps an Indiana offense that has been rolling of late, as the Hoosiers sit inside the top 5 in passing success rate and lead the nation in points per quality possession (all drives across the opponents 40-yard-line). Fernando Mendoza certainly looks like one of the better quarterbacks in the nation to this point and the Hoosiers have plenty of skill position talent at their disposal against an Illini secondary that has certainly struggled in the lone game where they had to play a competent offense. The Indiana offensive line is also quite strong, and it should hold an edge in this game against an Illinois defensive front that has yet to face a unit of this caliber.

On the other side of the ball, I’m still not sold on Luke Altmyer and the Illinois passing attack. Despite the fact that the Illini receivers did step up against Duke, that performance has not aged particularly well, seeing as we just saw Tulane make quick work of the Blue Devils’ defense, to the tune of nearly 7 yards per play. The Illini have also struggled with generating explosiveness on offense, particularly in the passing game (69th in passing explosiveness), and that factors in games against Western Michigan and a very poor Western Illinois team. Indiana’s defense is an experienced veteran group and the Hoosiers will certainly be looking to generate turnovers against an Illinois side that has not thrown an interception or lost a fumble to this point in the season. Ultimately, I’m getting to back a great coach in Curt Cignetti, plus the better quarterback in this game at home. I’ll trust my instincts and lay the number with the Hoosiers.

Illinois vs Indiana prediction: Indiana -4 available at time of publishing. Playable to 4.5

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Caleb Wilfinger
Game Totals Pick
Under 53.0(-110)

These teams both have the capability to be very explosive, and we’ve seen as such in each of their first 3 games. However, this is a step-up in class for both sides on Saturday, and this game should be played at a lot slower of a pace on a down-to-down basis. After all, both of these teams are outside the top 100 in plays run per game, along with similar marks in plays per minute. Couple that with the fact that Indiana has been a particularly strong side in terms of controlling the clock, and all signs are pointing to a more deliberately played game in Bloomington. With that in mind, it’s not a shock that the market has come down a bit off the opener of 54 for this game. It’s not my strongest play on the board by any means, but I’ll take the under at the current number.

Under 53 available at time of publishing. Playable to 52.5

Caleb Wilfinger

College Football Picks This Week

With so many conferences and hundreds of matches played every weekend, the biggest test with any college football picks is unearthing those hidden gems. Here at Pickswise, that is exactly what we do. By focusing on the Power conferences and the Top-25 teams, along with a select number of other matches, our experts can focus on the key games and leave no stone unturned in our research. Pickswise is the home of free NCAAF picks, and we break down all of today’s college football action, with each pick coming with accompanying analysis, including all of the key stats, trends, and reasons for our pick.

Be sure to check back each week during the season for all of our top college football picks today.

Expert College Football Picks Against The Spread (ATS)

The most popular college football pick is against the spread (ATS). Against the spread betting isn’t about picking a winner of the football game, it’s about picking the team who will cover the spread.

Let’s say you bet your money that Team A covers the spread (wins by a certain amount of points), Michigan State -6.5 for example. Or that Team B will cover the spread (keep the game closer than oddsmakers expect), Ohio State +6.5. If Michigan State beat Ohio State 30-27, then Ohio State covers the spread, and underdog backers are cashing tickets with +6.5 on Ohio State.

Against-the-spread betting is extremely popular in football and that’s one of the main reasons why it’s one of the most popular college football picks on our site.

NCAA Football Today – Today’s NCAAF Picks

At Pickswise we cover all of the Power NCAA football today, with full game previews, picks, and betting analysis brought to you by our college football experts. A typical college football season runs from August to December and is preceded by the College Football Bowl Season and College Football Playoff, culminating in The College Football Playoff National Championship game in January.

When Do You Post Your College Football Picks

We post our college football picks for this weekend a couple of days before the scheduled match. We post our picks early enough so that you can digest the information, do your own research into the match, and make sure you get the best lines and odds for that particular pick. Like anything in sport, some things are unpredictable, and on occasion, we may choose to delay posting a pick if there is something like a key injury or likely conditions that could have an impact on the outcome of the match, or our pick itself. Check back leading up to the weekend every week throughout the season to see what NCAAF Picks we have for today.

Free Expert NCAAF Picks

All of our NCAAF picks are absolutely free, all season long. We have a team of expert NCAAF handicappers on hand to preview the very best of the Power conference or Top-25 ranked match, every week, all season long. Each of these previews comes with our experts’ NCAAF pick on the three main markets (Money Line, Spreads & Totals) with a full breakdown of why they like a particular side, as well as a confidence rating for each individual NCAAF pick. You can find every NCAAF pick throughout the season right here on the NCAAF Picks page, or check out our NCAAF Parlays for even more insight into betting better on NCAA Football this week.

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