Alabama Crimson Tide vs Missouri Tigers Prediction, Odds and Picks for Today, 10/11/25

Let’s kick some numbers – Missouri has never beaten Alabama since joining the SEC, while the Tide have won each of the 5 victories by double digits. Guess what? They have been laying double-digits to Mizzou as well. This number, to be frank, sticks out like a sore thumb.

However, the Tide come in off 2 statement performances in recent weeks. First, ending the 33-game win streak in Athens and defeating a top-5 Georgia team. Bama followed that up with a win and cover as a 12.5-point favorite against Vanderbilt, who came in undefeated off the heels of last year’s shocker in Nashville that saw the Dores upset Alabama — who was ranked the top team in the polls then. Alabama won the rematch in Tuscaloosa by 16, put the trendy dog to bed and ripped up a lot of tickets while doing so.

So what happens now? The market overreacts and they are jumping aboard the Tide a week after the Vandy win, in a spot that looks conducive for another W. However, despite Alabama’s dominance in this series, this is the shortest number they have spotted to the Tigers. Meaning, Missouri has its best chance right here to finally beat Alabama and push the Tigers to 6-0. Missouri is the SEC team no one is talking about, but that changes after this weekend. Tigers outright.

Alabama vs. Missouri prediction: Missouri Tigers ML (+130) available at time of publishing. Playable to +115.

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