Alabama Crimson Tide vs South Carolina Gamecocks Prediction, Odds and Picks for Today, 10/25/25

If this were Week 1, this game would have a completely different connotation. Not too long ago, the Gamecocks were ranked and Alabama wasn’t on the back-end of 4 straight ranked wins against conference opponents. These are 2 sides trending in opposite directions, and now South Carolina is being offered at a number that cannot be passed up.

Not only do the points look good here, but USC looks tempting as an outright proposition on the money line, and such maybe worth a consideration for those that are adventurous. But for our official pick, we’ll stick to the point spread. South Carolina in many ways is reminiscent of Florida State. The Gamecocks have a physical and dynamic quarterback in LaNorris Sellers, who could give Alabama’s rush defense fits like Tommy Castellanos did. Let’s not also forget that South Carolina has one of the most animated home environments in all of the SEC, which will make things difficult for the Tide. On the road this season, Alabama has looked mortal. Georgia and Mizzou made mistakes that helped Alabama to escape with a field-goal win, while the Tide’s biggest wins of the year against Vandy and Tennessee were in Tuscaloosa. This is a completely different animal if South Carolina doesn’t do the Tide any favors.

We know the Gamecocks were buried by the Oklahoma and looked like they are dead in the water, but that sets the table for the unthinkable. Alabama will not walk into Columbia and simply have it’s way. Upset potential is high here, and it would not be surprising by the least. This number is inflated due to recency bias, and those backing the Gamecocks get to take advantage. Grab the points.

Alabama vs. South Carolina prediction: South Carolina Gamecocks +13.5 (-110) available at the time of publishing. Playable to +13.

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