Arizona State Sun Devils vs Iowa State Cyclones Prediction, Odds and Picks for Today, 11/01/25

The Iowa State Cyclones started this season as a potential College Football Playoff team, but are now just hoping to put an end to their 3-game losing streak when the Arizona State Sun Devils come to visit this weekend. Iowa State’s losing streak includes a 38-30 loss at Cincinnati, a 24-17 loss at Colorado, and a 41-27 loss at home against BYU last weekend. Quarterback Rocco Becht has struggled during the streak, throwing for 3 touchdowns and 4 interceptions. Arizona State hasn’t won much in their last 3 games, either. In fact, the Sun Devils lost 2 of their last 3 games, and now sit with a conference record of 3-2. Arizona State’s last game was a 24-16 loss to Houston in which the Cougars scored the first 24 points of the game while holding the Sun Devils scoreless until the fourth quarter. Last year’s Big 12 championship matchup is now just two teams trying to get back to their winning ways.

The main storyline for this game is that Arizona State’s starting QB Sam Leavitt won’t play, as he went down with an injury against Houston. Leavitt has thrown for 1,628 yards and 10 touchdowns this season. He was one of the main contributing factors towards Arizona State’s Big 12 championship last season. Replacing Leavitt will be senior quarterback Jeff Sims. The most prominent time in Sims’ career was in 2020 and 2021 when he started for Georgia Tech. Sims has thrown for over 5,000 yards in his college career, so he certainly will be able to comfortably fill the role this Saturday.

I have reasonable concerns with the Cyclones and their consistency. There are times where they show their greatness, and there are other times where seemingly nothing goes right for this team. In both losses against Cincinnati and BYU, the Cyclones fell into a hole in which they allowed their opponent to go on a scoring run of 20 or more unanswered points. Overall, they rank as a middle of the pack offense and defense, and I don’t believe they have done enough to merit being over a touchdown favorite. 

Arizona State vs Iowa State prediction: Arizona State Sun Devils +7 (-110) is available at the time of publishing. Playable at that number.

You can bet on our Arizona State vs Iowa State pick at DraftKings Sportsbook, which has thousands of betting options available and a great new customer offer where you can get $200 in bonus bets instantly AND $200 off NFL Sunday Ticket! Click here 👈🏼 to sign up for a DraftKings account now.