Arizona State Sun Devils vs Mississippi State Bulldogs Prediction, Odds and Picks for Saturday, 09/06/25

This number absolutely stinks. Let’s profile both combatants. Arizona State is flirting with a top-10 ranking, fresh off a CFP appearance and Big 12 title in 2024. Many analysts have touted the Sun Devils as the best team in the Big 12 with Kenny Dillingham at the helm, moving forward. There was no trouble in Week One for ASU in dispatching a FCS opponent. No scare, no upset alert, just pure dominance and control. Now, we have the Bulldogs who were the worst team in the SEC in 2024, upset by Toledo in Starkville and decisively so, on upset alert heading into their tilt with Southern Miss, last Saturday. The Dogs didn’t dismantle the Golden Eagles, they won by 17 as a 14-point favorite. So the line makes no sense here.

Chances are if this game plays out as the linesmakers prognosticate, the Bulldogs are going to be in position to pull the upset. If Mississippi State is going to be with a touchdown of a top-10 ranked team, there is a good chance that some mayhem is going to unfold and that’s why I am saying keep the points, we’ll go for the outright win with Mississippi State. If you want to play it conservative, sure, grab the converted touchdown and make it a half-unit play. But I don’t think you’ll need it. The line smells a rat, and more chaos continues Week Two with another ranked team going down. Arizona State is not the same ASU as last year and neither are the Dogs for that matter. Bulldogs win.

Arizona State vs. Mississippi State prediction: Mississippi State +210 (Money Line) available at time of publishing. Playable at that number.