Arizona Wildcats vs Arizona State Sun Devils Prediction, Odds and Picks for Friday, 11/28/25

It is rivalry week in college football, and that means it is state championship week in Arizona. The Arizona Wildcats make the trip upstate to face the Arizona State Sun Devils. Both teams sit at 8-3 overall, and the Sun Devils are hoping to inject some chaos into the conference’s final week. They can still make the conference championship game with a win and a lot of help, but the visiting Wildcats actually come in as slight favorites. ASU is 5-1 at home, including a win over Texas Tech, so it is hard to bet against Dillingham and Co in Tempe. But I do think the Wildcats have found something in the second half, so I am going to side with Arizona at only -2.

Much of the story of this game will be the defenses. The basic idea here is that you cannot run the ball against Arizona State, and you cannot throw the ball against Arizona. That makes both teams heavily one-dimensional. I do think Arizona and their first-year OC finally found a rhythm and have discovered some things as the season has gone along, and Fifita has really lit up the scoreboard of late. They want to be an up-tempo, pass-heavy system, and they are finally getting there. It is also worth remembering that ASU is playing without its starting QB, and their star WR has been fighting through a hamstring injury, and that makes it tough against an Arizona team that is so good against the pass. This is a rivalry game and everything can absolutely go haywire, but I see more paths to success for the Wildcats. I’ll cast my lot there.

Arizona vs Arizona State Prediction: Arizona -2 (-110) available at the time of publishing. Playable at that number.