Arizona Wildcats vs Cincinnati Bearcats Prediction, Odds and Picks for Saturday, 11/15/25

The Cincinnati Bearcats host the Arizona Wildcats on Saturday afternoon in a noon kickoff. The Bearcats took their first conference loss of the season last week when they were pushed around by Utah on the road, but that happens to a lot of people. The Bearcats look to bounce back and keep themselves in the hunt for a conference title when they host the Wildcats. Arizona grabbed a key road win at Kansas last week. For a team that was expected to finish near the bottom of the Big 12 standings, Arizona is a sneaky dangerous team. They are now bowl eligible and in the middle of the pack in the conference. Still, I like the Bearcats to cover at home, and I will take the -6.

I do think Arizona is a sneaky team, and they have some weapons. Their up-tempo offense can put a defense on its heels in a hurry. Cincinnati will need their pass rush to be disruptive, especially if Noah Fifita holds onto the ball too long. My concern for Arizona is their defense. Cincinnati is a team that spreads out the defense horizontally, runs underneath when the numbers dictate, and then beats you over the top when they see a chance. If Arizona struggles against the run early, Cincinnati could exploit it. The Bearcats have been great at home, and when west coast teams have noon starts on the other side of the country, that typically goes poorly. If this game were in the desert, I might be thinking upset, but not at Cincinnati. Give me the Bearcats to cover and get back on track.

Arizona vs Cincinnati Prediction: Cincinnati -6 (-110) available at the time of publishing. Playable at that number.