Boston College Eagles vs Louisville Cardinals Prediction, Odds and Picks for Today, 10/25/25

After a huge 24-21 win over Miami that widely opened the ACC title race, the newly-ranked Louisville Cardinals will welcome in the 1-6 Boston College Eagles. Louisville bounced back from its only loss of the season with a big win over 2nd-ranked Miami. Quarterback Miller Moss threw for 248 yards passing and 2 touchdowns, while running back Isaac Brown led the Cardinals with 113 yards rushing. Louisville’s defense was the main headline in the win, intercepting Miami’s quarterback Carson Beck 4 times in the victory. Louisville currently ranks 27th in the FBS with a +4 turnover margin. Boston College has struggled this season after a win to open the season, losing 6 straight – all against FBS opponents. It has seemingly gotten worse for the Eagles, as their last 3 losses were all by double digits. Boston College made a change at quarterback last week, promoting senior quarterback Grayson James against Connecticut. James threw for 204 yards and 2 touchdowns in the loss.

It has been a rough 3 weeks for Boston College’s defense. In their last 3 losses, the Eagles have surrendered on average 487 yards to their opponents and 42 points per game. In years past, defense was a strength for Boston College, but due to a combination of players graduating and injuries to its linebacking group, there is not much for a path towards improvement for BC. Louisville will have the opportunity to move the ball effectively this Saturday, as Boston College currently ranks 117th against the pass. The Eagles also rank 134th in the country in stop rate. Offensively, Boston College showed signs of life under James. The Eagles won the time-of-possession battle against Connecticut and totaled 24 first downs. I don’t think there is a way they can keep up with Louisville, but if Boston College can score enough offensively, this game should be able to get over the total.

Boston College vs Louisville prediction: Over 55 is available at the time of publishing. Playable at that number.

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