California Golden Bears vs Virginia Tech Hokies Prediction, Odds and Picks for Friday, 10/24/25

Friday night’s ACC contest sees the California Golden Bears facing the Virginia Tech Hokies. Last Friday brought us some fireworks as Louisville upset Miami; this week, we move considerably further down the card for this matchup. Cal has already exceeded expectations this year as they come into the game with a 5-2 mark, while the Hokies made a midseason coaching change on the way to a 2-5 record. They have dropped consecutive games to Georgia Tech and Wake Forest, but also had a bye week to reset. Still, I don’t like much of anything going on in Blacksburg right now, so I am taking the Golden Bears +4.5.

Cal is certainly not great, but their defense has been competent and has kept them in games. They generate just enough offense through the air, and Virginia Tech has some weaknesses in the secondary, which should favor Cal. We usually want to fade these cross-country ACC trips, but this is a night game and not a noon start, so that shouldn’t be too much of a factor. The Hokies are in a freefall, and they have only covered once in 7 games. Even if Tech wins this game, I don’t see them running away with it against much of anyone. Give me the points with Cal in this spot.

Cal vs Virginia Tech Prediction: Cal +4.5 (-110) available at the time of publishing. Playable at that number.