Charlotte 49ers vs Georgia Bulldogs Prediction, Odds and Picks for Saturday, 11/22/25

Georgia enters this matchup looking every bit like the best team in the nation, and this spot against Charlotte sets up as another opportunity for the Bulldogs to show how far ahead they are of most opponents. Last week’s 35–10 dismantling of Texas in Athens was another indication that this team is hitting its stride, particularly on the defensive side of the ball, where they continue to generate short fields and even direct scoring opportunities. The week prior, they handled Mississippi State by 21 on the road, controlling every phase from start to finish.

Laying this many points is never comfortable, and Georgia has no incentive to run up the score unnecessarily. But the danger with fading the Bulldogs comes from the fact that they score in all three phases. Their defense pressures every snap, creates turnovers, and often converts those into points. Their special teams consistently flip the field and have the talent to break a return at any moment. When you combine that with an offense that’s improving weekly and a coaching staff emphasizing continued growth, the margin can escalate naturally. Charlotte simply doesn’t have the personnel to hold up for four quarters, and Georgia’s depth ensures the level rarely drops when backups rotate in. Even without forcing the issue, Georgia can get into the high 40s, and if the defense sets up or produces a score or two, covering becomes very realistic.

Charlotte 49ers vs Georgia Bulldogs prediction: Bulldogs -43.5 (-110) available at time of publishing. Playable to -44.