Cincinnati Bearcats vs Oklahoma State Cowboys Prediction, Odds and Picks for Saturday, 10/18/25

The Cincinnati Bearcats head to Boone Pickens Stadium on Saturday night to face the Oklahoma State Cowboys. The Bearcats find themselves atop the conference standings at 3-0, 5-1 overall, and with a reasonably favorable schedule remaining. Oklahoma State, of course, is in the midst of a disaster season, where they are in last place in the conference and have already made a coaching change. As a result, the spread on this game is unsurprisingly high. I do not mean to imply that the Cowboys are good, or even figuring things out, but I do think this number is too large. I’ll take Oklahoma State to cover +21.5 at home.

The problem for the Cowboys is that they are one of the worst defenses in the country, and especially on the passing side. And Cincinnati excels in the passing game. On the other hand, the Bearcats are not a very good defensive team overall, and this is a decent spot for Oklahoma State to put up enough points to cover. Cincinnati has been a surprise; I do think they have overperformed, and they will experience some regression in the second half of the season as teams get more film on them. This game will probably have a lot of points, but as long as OSU is putting up their fair share, they should cover a big number in their home stadium.

Cincinnati vs Oklahoma State Prediction; Oklahoma State +21.5 (-110) available at the time of publishing. Playable at that number.