Clemson Tigers vs Louisville Cardinals Prediction, Odds and Picks for Today, 11/14/25

We have Friday night ACC action as the Clemson Tigers face the Louisville Cardinals. When this game was first scheduled, I am sure people thought it would be important for different reasons, as Clemson was expected to be a playoff contender, not Louisville. But the Tigers have been a massive disappointment, as is well documented, sitting at 5-4 and fighting for mere bowl eligibility. The Cardinals took a big setback last week when they dropped a home game to Cal. That dropped the Cardinals to 7-2 overall, including 2 conference losses, and trailing 5 teams with only a single loss. Louisville will have to work hard to avoid the letdown spot here, but I think they are the better team, so I am backing the Cardinals at home to cover -3.

Perhaps the biggest problem for Clemson this season has been their inability to stop the passing game. They actually rank outside the top 100 in terms of passing yards allowed per game. Louisville should be able to find some big plays in the passing game. I look for that to be the difference in the game. The Louisville defense is stout, and they have held up against good opponents like Miami, Virginia, and Pitt, and I think all of those offenses are more dangerous than this year’s Clemson offense. Playing at home on a Friday night with a short line looks like a good play to me. Give me Louisville -3.

Clemson vs Louisville Prediction: Louisville -3 (-110) available at the time of publishing. Playable at that number.