Clemson Tigers vs South Carolina Gamecocks Prediction, Odds and Picks for Saturday, 11/29/25

Neither Clemson nor South Carolina has much to play for entering the final week of regular season play. However – for what it’s worth at this point – Clemson has turned a nightmare season around in recent weeks with 3 straight wins including victories over Florida State and a top-20 Louisville team on the road. Despite putting up 51 points against a measly Coastal Carolina squad last time out, the underlying numbers for the Gamecocks’ offense are rough. South Carolina ranks 121st in offensive success rate and 106th in net points per drive offensively.

Quality drives are few and far between for South Carolina in 2025, largely due to an immense struggle to establish a consistent run game. This bodes poorly in this matchup as Clemson has an above-average defensive unit against the run, ranking top-50 in practically every major stat category relating to run defense. After the collapse against the Aggies two weeks back, it’s hard to have any faith in the 4-7 Gamecocks. I’ll take Clemson to close the season strong with a cover on the road.

Clemson vs South Carolina prediction: Clemson Tigers +3 (-110) available at time of publishing. Playable at that number or better.

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