Colorado Buffaloes vs Kansas State Wildcats Prediction, Odds and Picks for Saturday, 11/29/25

Head coach Deion Sanders and the Colorado Buffaloes will travel to the University of Kansas State this Saturday to take on the Wildcats. Colorado has a record of 3-8 this season, and they currently sit near the bottom of the Big 12 with a Conference record of 1-7. They have lost their last four games, with their last loss coming against Arizona State 42-17. Colorado actually had a 14-13 lead in this game, but some poor tackling on defense allowed Arizona State to break this game open in the 4th quarter with 21 unanswered points. Their opponent this week, Kansas State, has a record of 5-6 this season, and a conference record of 4-4. The Wildcats have won three of their last five games, with their last game resulting in a loss to Utah 51-47. It was a career game for running back Joe Jackson. He ran for 293 yards and 3 touchdowns against a solid Utah defense. Despite the effort, Kansas State could not hold on to a 47-35 lead with 7 minutes left in this game. Kansas State will now need a win over Colorado to be bowl game eligible.

Coach Sanders made the decision before Saturday’s game that his starting quarterback Julian Lewis will not start this Saturday’s game so that he can preserve his redshirt freshman season. That means the Buffaloes will go back to Kaidon Salter as their quarterback to end the season. Salter was the team’s starter at the beginning of the season. He threw for 1242 yards, 10 touchdowns and 6 interceptions in 8 games played this season. Due to his play that regressed as the season continued, the team decided to bench Salter. But now the senior quarterback has the opportunity to end his career the right way against a Kansas State defense that allows 392 yards and allows 27.8 points per game this season. One of Salter’s best attributes this season is his rushing ability. Despite not playing the past two games, Salter still has the second most rushing yards this season for Colorado with 293 yards. Kansas State’s offense has been playing great football down the stretch, and I expect their offense to show up in a must-win game against a Colorado defense that has allowed big plays all season, and I do think we get enough out of Salter in his last collegiate game to cover this total.

Over 49.5 is available at the time of publishing. Playable at that number.