Colorado Buffaloes vs Utah Utes Prediction, Odds and Picks for Saturday, 10/25/25

The Utah Utes are coming off a close loss on the road against BYU, back home in Salt Lake City with a bounce-back spot as double-digit favorites over the Colorado Buffaloes. This is an interesting spot for Colorado; it played its best game of the season in a 24-21 win over then-ranked Iowa State last week but has struggled significantly in its only 2 road games in 2025. The Buffs had 6 turnovers in 2 road games this season, losing both by a 2-possession margin against unranked TCU and unranked Houston. 

The issue for the Buffaloes this time around is that neither of the aforementioned defenses come close to the efficiency and talent that this Utah unit has posted in 2025. Colorado has really only found success in the passing game, ranking 127th in rushing success rate compared to 48th in passing success rate. The Utes have primarily done well against the pass, ranking 12th in EPA/dropback and 10th in success rate when defending the pass while allowing just 155.4 passing yards per game. On the other side of things, this Utah offense has been fun to watch with Devon Dampier under center. The dual-threat QB has helped the Utes to a top-10 mark in EPA/dropback, quality drive rate and points per quality drive. With all things considered, I’ll take Utah to cover at home.

Colorado vs Utah prediction: Utah -12.5 (-110) available at time of publishing. Playable at that number.

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