Colorado Buffaloes vs West Virginia Mountaineers Prediction, Odds and Picks for Saturday, 11/08/25

Two teams that sit near the bottom of the Big 12 Conference will meet this Saturday when the Colorado Buffaloes take on the West Virginia Mountaineers. Both teams have an overall record of 3-6 and a conference record of 1-5. Colorado has lost four of their last five games. They were defeated 52-17 on their home field by the Arizona Wildcats last Saturday. The Buffaloes defense allowed big plays early and often against Arizona. They allowed Arizona’s quarterback, Noah Fifita to throw for 4 touchdowns before halftime. The Buffaloes played well below expectation, getting blown out as only 3.5-point underdogs. West Virginia was able snap a five-game losing streak with a 45-35 win over 22nd ranked Houston. The game was played in Houston, Texas, and the Mountaineers were able to win outright as 12.5-point underdogs. It was the third start that West Virginia turned to freshman quarterback Scotty Fox Jr. Fox threw for 157 yards and 1 touchdown, and he ran for another 65 yards and two touchdowns. Fox looked more confident than he has than in his previous starts, and West Virginia was able to outgain a talented Houston offense.

The Colorado Buffaloes have become frustrated with the play of quarterback Kaidon Salter, and they will look to turn to true freshman quarterback Julian Lewis this Saturday. Salter’s play decreased in the past two games, where he only threw for an average of 43 yards per game. Lewis did see playing time against Arizona. He was 9 of 17 for 121 yards and 1 touchdown. Most of that time did come in the second half when Colorado was already down by a couple of scores, so this Saturday will be Lewis’ first action during a meaningful period. In the battle of freshman quarterbacks, I’m leaning towards Fox Jr. Fox has shown a lot of growth even in his last 3 starts. He led the Mountaineers to 45 points against a solid Houston defense. Against Colorado’s defense, which ranks 113th in the FBS with an average of 426 yards per game allowed, Fox should be able to continue his upward trend. West Virginia has some impressive wins this season against Pittsburgh and Houston. They just now need to learn to be consistent. They have a good chance this Saturday by putting together back-to-back wins.

West Virginia -6.5 is available at the time of publishing. Playable at that number.