Connecticut Huskies vs Syracuse Orange Prediction, Odds and Picks for Saturday, 09/06/25

There are a couple points to consider here. First, there is Syracuse who left its backers out to dry last week as a +14 underdog against Tennessee. Let’s take you back. In the closing minutes of the contest, Syracuse had a chance to punch the ball into the end zone and bring Orange backers under the number. Tennessee however would bow its neck and keep Cuse out, winning by 19. That’s a tough pill to swallow, and it makes Syracuse a tough team to ride in their follow up.

Then there is the Huskies, who covered easy last week as a 26.5-point favorite, covering their biggest number in recent memory with relative ease against Central Connecticut State. This is important to remember, because the Orange opened as a 7.5-point favorite. This number is a number designed for the Orange, not the Huskies because even if Cuse wins by a touchdown, UConn backers green up. Seldom does the half point actually factor into the math, but there is an illusion of safety in taking the up-start underdog who was been cashing tickets like a maniac since the tail end of 2024. The Huskies have since resurrected their program and won nine games last season, that storyline is carrying over despite Syracuse hitting the 10-game threshold in 2024. But the ugly loss to the Vols has erased that from perception.

Syracuse had a lot of self-inflicted wounds against Tennessee and with that being said, Coach Fran Brown had the Orange playing with the Tennessee for large segments of the contest. Remove the mental blemishes and Cuse covers easy last week, and perhaps even gives the Vols a scare. They’ll bounce back in a big way this week against the Huskies who are without question, getting too much love here. Lay the points.

Connecticut vs. Syracuse prediction: Syracuse -7 (-110), available at the time of writing. Playable to Syracuse -8.