Delaware Fightin' Blue Hens vs Colorado Buffaloes Prediction, Odds and Picks for Saturday, 09/06/25

On paper, this is a bounce-back game for the Buffaloes after underdoing a bitter 27-20 defeat to the Ramblin’ Wreck of Georgia Tech, last Friday. Delaware comes in off a 35-17 win over cross-state rival Delaware State in the Route 1 Classic, last Thursday. The Hens failed to cover as a 30.5-point favorite while doing so, despite much of the market siding with the team from Newark who never lost to the team from Dover in the history of the rivalry. So what we have is two ingredients – Colorado in a spot where they can get right after falling as a 4.5-point underdog in the final quarter of play against a team that didn’t look the part, last week, despite getting a win.

However, Delaware was prone to be overvalued against D-State because the fact of the matter is, they’ve been perfect against them. With such supermacy often comes a price, but now the opposite is the case here. This is Delaware’s first game as a FBS member against a Power Four opponent and with that comes an inflated number next to the Hen’s logo. Add in the fact that they didn’t cover last week, that number bloats. Whether Colorado clobbers the Blue Hens or not is irrelevant because the Buffaloes still have a lot of hype and rhetoric behind them. That makes Colorado the team to approach with caution and it is not conducive to lay this amount of points with the Buffaloes still perhaps reeling from last week’s bitter loss. Grab the points.

Delaware vs. Colorado prediction: Delaware +23.5  available at time of publishing. Playable to +23.