Delaware Blue Hens vs Wake Forest Demon Deacons Prediction, Odds and Picks for Saturday, 11/22/25

The Wake Forest Demon Deacons have had a solid year in the ACC up to this date, but they will get a break from conference action this week when they go head-to-head against the Delaware Blue Hens out of Conference USA. Wake Forest has won 5 of its last 6 games. The ‘Deacs won their last game 28-12 against North Carolina, and the offense against a UNC defense that has stared to find its footing. Wake Forest ran the ball 39 times for 223 and 3 touchdowns, and quarterback Robby Ashford threw for another 191 yards and 1 touchdown.

Delaware has a record of 5-5 this season, and the Hens hope to bounce back from a 26-23 loss against Sam Houston last week. Quarterback Nick Minicucci threw for 338 yards and 1 touchdown in this game, but the Blue Hens could not slow down Sam Houston’s running game – allowing 139 yards rushing and 2 touchdowns.

Delaware has some experience playing against a Power Four school this season. The Blue Hens fell short against Colorado 31-7, but following that loss back in the beginning of September, Delaware’s offense has scored 23 or more points in each game. Delaware’s offense is powered by one of the top passers in college football, Nick Minicucci. Minicucci is 2nd in all of college football with 3,063 yards passing this season. His favorite targets this season have been Sean Wilson and Kyre Duplessis, who have combined for 1,353 yards receiving and 7 touchdowns.

Wake Forest’s running game should be able to pick up where it left off, and if the Blue Hens’ defense plays like they did against Sam Houston, they should be able to break loose for a couple long runs, too. Wake Forest should be able to take this game, but I think the Delaware offense does enough to push this game over.

Delaware vs Wake Forest prediction: Over 51.5 is available at the time of publishing. Playable at that number.

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