Duke Blue Devils vs Clemson Tigers Prediction, Odds and Picks for Today, 11/01/25

Both teams are known for their defensive acumen and the disruptive play of their defensive fronts. Each side prefers to establish the run and control tempo, which is always a recipe for an under before we even dig into the details. These are physical, methodical teams that thrive on wearing opponents down rather than lighting up the scoreboard.

Turnovers will play a factor, too. Both Clemson and Duke have been prone to mistakes, but they also feed off takeaways — which often lead to short fields and stalled drives rather than shootouts. It’s hard to envision how either offense finds a path to 55 total points when each has struggled to score consistently against quality defenses.

Clemson’s offense has looked ordinary when facing resistance, and Duke’s production dips noticeably against opponents that can match their line play. When either team has met a defense capable of pushing back, they’ve both struggled to break the 21-point threshold.

This one shapes up as a grind-it-out contest — long drives, field position battles, and plenty of punts. Defenses dictate the pace from start to finish. The under is the prudent play here, and 55 feels a touch too generous.

Duke vs. Clemson prediction: Under 55.5 (-110) available at  time of publishing. Playable to Under 55.

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