Eastern Illinois Panthers vs Alabama Crimson Tide Prediction, Odds and Picks for Today, 11/22/25

Alabama finds itself in an unusual spot this week. Just seven days ago, the Tide were the most heavily-backed side on the college football board as a six-point home favorite against Oklahoma. Not only did they fail to cover — they lost outright, 23-21. That result dramatically changes the market’s perception heading into this matchup with Eastern Illinois. Suddenly, bettors will be hesitant to lay a big number with Alabama, and as a result, we’re getting the Tide cheaper than we would’ve had they handled their business last week.

This becomes an ideal bounce-back situation. With Auburn looming and playoff hopes now extremely fragile, Kalen DeBoer has every incentive to sharpen his team and eliminate the sloppiness that cost them against the Sooners. Alabama rarely stacks poor performances back-to-back, and this is exactly the type of opponent they can use to reset their rhythm, establish physical dominance, and get their confidence in order before the Iron Bowl. Eastern Illinois simply doesn’t have the personnel to keep Alabama uncomfortable for four quarters, and emotionally, the Tide should be fully locked in. Last week’s loss creates urgency, and a focused Alabama team laying a discounted number is a spot worth playing. This is a classic “take it out on the opponent” setting.

Eastern Illinois vs Alabama prediction: Alabama -50.5 at the time of publishing. Playable at that number or better.

If you’re looking for a new sportsbook for the football season, we recommend checking out Fanatics Sportsbook. New users can get $250 in FanCash INSTANTLY when they make their first $50 wager! Join Fanatics Sportsbook, where you can bet on our Eastern Illinois vs Alabama predictions.