Florida Gators vs LSU Tigers Prediction, Odds and Picks for Today, 09/13/25

One of the headliner games of Saturday’s slate is the SEC clash in Death Valley between the Florida Gators and the LSU Tigers. LSU is off to a strong start, finally getting over the hump and winning a season opener with what is probably the most talented roster that Brian Kelly has had anywhere. The Gators come to town fresh off a loss to South Florida, and while the whole world overreacts to that, we also need to step back and realize that the Bulls are actually really good. I’m not ready to bury Florida, fire Napier, or any of that, but they are heading to what might be the most hostile nighttime college football environment on the planet, and this is just not a game you are supposed to win.

DJ Lagway has a talented Gator roster around him, and I think they will be fine as the season goes along. They still have maybe the nastiest schedule in the SEC though, and that starts with a trip to Death Valley. There is no way to prepare for the noise and power of that stadium, and it will inevitably lead to mistakes. Lagway is a great talent, but he is also young, and this is a big moment. The LSU defense is elite, and I expect this defense to control the game. The talent on the offensive side for the Tigers is top notch, and they should score. This could be a 10 point game, or it could be a landslide, but I would be shocked if it is just a field goal. Give me the Tigers to cover.

Florida vs LSU Prediction: LSU -7.5 (-110) available at the time of publishing. Playable at that number.

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The books have handed us a tough number here, but I like the under. I think this game will be heavy on the defense, and if points come at a premium, I expect offenses to take field goals when they get the chance. I also expect both teams to be willing to punt the ball away and rely on their defensive units. If you are Florida, I don’t think you come into this game expecting that you can win a shoot-out. You would have to plan on conservative, safe offense and reliance on your defense. There shouldn’t be much checking off at the line either. This just seems like a game that ought to finish in the low 20s.

It is worth knowing that LSU brought in the top-rated transfer class in the country, and much of that was on the defensive side. I think the Tigers have a defense that can line up with anybody, and they certainly expect to be able to compete in, and maybe even win, the SEC on the strength of that defense. LSU beat Clemson 17-10 and LA Tech 23-7; Florida lost to South Florida 18-16. Both teams are very much on the trajectory of unders at this point, and I look for that to continue. I’ll take my chances with the game total under 47.5.

Florida vs LSU Prediction: Under 47.5 (-110) available at the time of publishing; playable at that number.