Florida State Seminoles vs Clemson Tigers Prediction, Odds and Picks for Saturday, 11/08/25

Florida State looked like a team reimagined in a dominant 42-7 win over Wake Forest after a much-needed bye week. Now the Seminoles head to Death Valley to face a Clemson program that has gone off the rails in 2025. The Tigers have been inconsistent on both sides of the ball all season and have really struggled to get a consistent ground game going in particular. Clemson ranks 102nd in EPA/rush which is an area the Florida State defense has been stronger in, ranking top-35 in both EPA/rush and success rate against the run. 

While the Seminoles’ secondary has been an issue, the offense ranks first in FBS in yards per game (510.5) with some solid underlying numbers. Behind dual-threat QB Thomas Castellanos, Florida State ranks top-20 in several key metrics such as net points per drive, quality drive rate and points per quality drive. The Clemson defense has surrendered 80 points and 868 yards over the last two weeks and I don’t have much faith in the Tigers to turn things around in this matchup. I’ll take the Seminoles on the road.

Florida State vs Clemson prediction: Florida State +2,5 available at time of publishing. Playable at that number or better.