Georgia State Panthers vs Vanderbilt Commodores Prediction, Odds and Picks for Saturday, 09/20/25

Let’s start with the Commodores, who have quickly become one of the hottest teams in college football. Vandy has been on a spree, covering their first three of the year. Vanderbilt has also earned a Top 25 ranking and sit undefeated in their exploits. Last week, Vanderbilt hammered South Carolina in Columbia, 31-7 making a Heisman hopeful in Lanorris Sellers look like an afterthought. Before we go any further, the Dores went from a five-point dog at open to a 27-point favorite in one week. That’s a sign of a massive overreaction and when we add in their stock is elevated, the propensity for an overlay is extreme.

For Georgia State, they drag their feet in at 1-2 with only a FCS victory to their name. In FBS play, the Panthers have been blownout by Ole Miss and Memphis by a combined margin of 101-23. On paper, they should be a snack for the Commodores, especially considering that Vandy is looking to avenge a loss last year against this very squad. GSU is also 0-3 against the number on the year, so that narrative incentivizes the market to back Vanderbilt here at an inflated number. Will Diego Pavia and company get their vindication? Sure but will they also cover a substantial number? That we’re not sold on, betting Vanderbilt here is simply laying too many points because of the contrasting trends both teams are projecting. Grab the points.

Georgia State vs.  Vanderbilt prediction:  Georgia State +27 (-110) available at time of publishing. Playable to number posted.