Houston Cougars vs Arizona State Sun Devils Prediction, Odds and Picks for Saturday, 10/25/25

We have a surprisingly important Big 12 showdown in the desert on Saturday night as the Arizona State Sun Devils host the Houston Cougars. Both teams sit at 3-1 in the conference standings, only a game behind BYU and Cincinnati (yes, those teams are somehow in first place). Arizona State won at home last week against Texas Tech while the Red Raiders played with a backup QB. Houston has won the games they are supposed to win, and their only loss came at the hands of the Red Raiders. Even in that game though, the Houston defense played really well. I think this game is going to be a tight battle, and I like taking the points with the visiting Cougars at +7.

Arizona State is dealing with some injury issues, and none bigger than star wideout Jordyn Tyson. The likely top WR in the upcoming draft, Tyson has already been ruled out this weekend with a hamstring injury. The Sun Devils are also dealing with some injuries on the defensive side of the ball as well, and those could end up making a sneaky difference that bettors are not baking into their math. On top of that, ASU has struggled with running QBs, and that is very much a part of the game for Houston QB Conner Weigman. Arizona State has a knack for finding a way to win, but they also frequently find themselves in those kinds of tight, one-possession games that need a heroic effort to win. I do not know if Houston can win, even with all the ASU injuries, but there is certainly a case to be made for them to keep this game close. Give me Houston plus the points.

Houston vs Arizona State Prediction: Houston +7 (-110) available at the time of publishing. Playable at that number.