Indiana Hoosiers vs Penn State Nittany Lions Prediction, Odds and Picks for Today, 11/08/25

What can we say? Indiana has been boat-racing just about everyone it has seen this year — with the lone exception being Iowa. Many will argue the Hoosiers could be the best team in the country, and it’s hard to push back. They’ve been balanced, explosive, and punishing – a dynamic offense, stingy defense, and an overall physicality that’s overwhelmed opponents. Indiana has been running teams over, make no mistake. Penn State, meanwhile, has been a disappointment in market terms. The Nittany Lions have covered just once all season and are coming off another ATS loss at Ohio State. In that game, PSU hung tough — down only 3 at the half as an 18.5-point dog — before getting blanked 21-0 in the third and never recovering.

So why back Penn State here? Value. In the summer look-ahead line, the Nittany Lions were as high as -16.5 in some spots. Now they’re catching over 2 touchdowns— an over 30 point market flip once you factor preseason expectations vs. current perception. That’s a classic buy-low underdog number, and this time it’s in Happy Valley. If there was ever a “right spot” for Penn State to rise up and turn its season narrative around, this is it. Don’t be shocked if the Nittany Lions don’t just cover, but flirt with the outright upset.

Indiana vs Penn State prediction: Penn State +15 (-110) available at time of publishing. Playable at that number.

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