Iowa Hawkeyes vs Nebraska Cornhuskers Prediction, Odds and Picks for Friday, 11/28/25

Last week, Nebraska was one of the public dogs of the weekend, taking back nearly double digits against a 4–6 Penn State team, and bettors lined up on the Cornhuskers thinking the price was auspicious. Penn State ended up blasting them 37–10, and just like that, the market has completely swung the other direction, now piling onto Iowa simply because the Huskers let them down. It also helps that the Hawkeyes have won nine of the last ten meetings.

But this line — sitting under a touchdown — is the giveaway. The oddsmakers aren’t willing to hang a big number despite Iowa’s dominance in the rivalry along with the fact they were a CFP hopeful, just weeks ago. That tells you Nebraska isn’t coming in flat. The Huskers were embarrassed last week, and teams often show their true form after a humiliation, especially when returning home against a rival that has had their number. Iowa’s offensive limitations always leave the door open, and the number suggests danger for the Hawkeyes. Forget the points, Nebraska pulls the upset.

Iowa vs Nebraska prediction: Nebraska +180 (Money Line) available at time of publishing. Playable to the number.