Iowa Hawkeyes vs USC Trojans Prediction, Odds and Picks for Today, 11/15/25

Last week, Iowa suffered a gut-punch at home against Oregon. The Hawkeyes were priced in almost the same range, bet down from +6 to +4.5, and for 59 minutes they looked like the right side to pull the upset —until Oregon’s walk-off field goal ended it, 18-16. That loss changes everything. A 3rd setback all but erases Iowa’s Big Ten and playoff hopes, and now the Hawkeyes have to regroup and travel west to face a USC team that’s still very much alive in both races.

That’s a tough emotional turnaround. We don’t know which Iowa team shows up—the one that defends with discipline or the one that struggles to move the ball for 4 quarters. USC, meanwhile, sits 7-2. Their 2 defeats—at Notre Dame and at Illinois—came in competitive efforts, and they remain positioned to sneak into the playoff conversation if they can win out. Motivation will not be an issue. The Trojans’ offense still hums, and at home, with everything to play for, this is a spot where their skill talent and tempo should overwhelm an Iowa squad coming off a draining, physical loss.

Iowa vs USC prediction: USC Trojans -6.5 (-115) available at time of publishing. Playable to -7.

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