Kansas Jayhawks vs Iowa State Cyclones Prediction, Odds and Picks for Saturday, 11/22/25

A midwestern, Big 12 matchup is set for this Saturday when the Kansas Jayhawks take on the Iowa State Cyclones. Kansas has a record of 5-5 this season and a conference record of 3-4. The Jayhawks have lost three of their last four games, including their last loss against Arizona 24-20. Quarterback Jalon Daniels led Kansas in passing and rushing yards. He threw for 199 yards and 1 touchdown, and he also ran for 74 yards and 1 touchdown. Iowa State has a record this season of 6-4 and a conference record of 3-4. The Cyclones were able to break a four game losing streak last game with a 20-17 win against TCU. Quarterback Rocco Becht was not his best, throwing for only 111 yards and 2 interceptions, but Iowa State was able to pull ahead late thanks to a punt return for a touchdown late in the 4th quarter. 

Both of these teams have fallen below expectations for this season. Iowa State was eyeing a Big 12 championship at the beginning of the season, and Kansas was looking to make more improvements from their disappointing 2024 season. As these teams are both looking to even up their conference records, I’m looking at the level of quarterback play from each team. Kansas is led by senior quarterback Jalon Daniels. Daniels has again put up a stellar season, throwing for 2190 yards, 21 touchdowns and only 3 interceptions. Daniels has been dynamic on offense, limited turnovers, and has looked great in recent games. Iowa State’s quarterback, Rocco Becht, has been the opposite. He has thrown for 2230 yards, 12 touchdowns, and 9 interceptions. Becht has been playing his worst football in recent games. Becht has thrown 7 interceptions in his last four games. Neither defense has played well, with both units allowing more than 28 points per game in their last five games, but right now I am trusting Daniels more with the football than I am Becht.

Kansas +4 is available at the time of publishing. Playable at that number.