Kansas Jayhawks vs Iowa State Cyclones Prediction, Odds and Picks for Today, 11/22/25

A midwestern, Big 12 matchup is set for this Saturday when the Kansas Jayhawks take on the Iowa State Cyclones. Kansas has a record of 5-5 this season and a conference record of 3-4. The Jayhawks have lost 3 of their last 4 games, including their last loss against Arizona 24-20. Quarterback Jalon Daniels led Kansas in passing and rushing yards, throwing for 199 yards and 1 touchdown, while he also ran for 74 yards and 1 touchdown.

Iowa State is 6-4 with a conference record of 3-4. The Cyclones were able to break a 4-game losing streak last time out with a 20-17 win against TCU. However, Quarterback Rocco Becht was not his best, throwing for only 111 yards and 2 interceptions. Iowa State was able to pull ahead late thanks to a punt return for a touchdown late in the 4th quarter. 

Both of these teams have fallen below expectations for this season. Iowa State was eyeing a Big 12 championship at the beginning of the season, and Kansas was looking to make more improvements after its disappointing 2024 season. As these teams are both looking to even up their conference records, I’m looking at the level of quarterback play from each team. Kansas is led by senior quarterback Jalon Daniels. Daniels has again put up a stellar season, throwing for 2,190 yards, 21 touchdowns and only 3 interceptions. Daniels has been dynamic on offense, limited turnovers, and is in great form.

Iowa State’s quarterback, Rocco Becht, has been the opposite, posting 2,230 yards, 12 touchdowns, and 9 interceptions. Becht has been playing his worst football in recent games, as he thrown 7 interceptions in his last 4 outings. In a game between 2 underperforming defense, I trust Daniels to succeed offensively much more than Becht. Give me Kansas.

Kansas vs Iowa State prediction: Kansas Jayhawks +4 (-110) is available at the time of publishing. Playable at that number.

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