Louisiana Ragin' Cajuns vs James Madison Dukes Prediction, Odds and Picks for Saturday, 10/11/25

James Madison is the frontrunner in the Sun Belt conference, off to a 4-1 start looking to keep rolling as heavy favorites at home against Louisiana. The Ragin’ Cajuns have seen a combined total of 105 points, 65 points and 62 points in its previous three contests. The defense has allowed an average of 45.6 points per game in that stretch, ranking 10th in total defense and 129th in defensive success rate. Louisiana has had significant struggles with stalling drives, and James Madison has been one of the more efficient offenses in the nation, ranking 15th in quality drive rate and 6th in points off those quality drives.

Despite the defensive struggles, Louisiana has managed to post 42.5 points per game on offense over its last two games. James Madison’s defense has been stout against non Power 4 teams this season, but even a pair of scores from the Ragin’ Cajuns could go a long way with a low total like this. The JMU offense should have a field day behind a top-10 rushing attack against this Louisiana defense, and I’ll take the over in this matchup.

Louisiana vs James Madison prediction: Over 45.5 (-110) available at time of publishing. Playable up to 46.5 (-110).