Louisville Cardinals vs Virginia Tech Hokies Prediction, Odds and Picks for Saturday, 11/01/25

The 16th-ranked Louisville Cardinals will try to keep pace with the top teams in the ACC with a win this Saturday when they travel to take on the Virginia Tech Hokies. Louisville has only lost one game this season. It was on October 4th when they fell in overtime against Virginia. The loss has now put the Cardinals behind Virginia and Georgia Tech, two teams that have not yet lost a conference game. The Cardinals need to continue winning if they want to compete for an ACC championship. Their last win was a 38-24 win over Boston College. Running back Isaac Brown had a big game, rushing for 205 yards and 1 touchdown. Virginia Tech currently has a losing record, but they are still 2-2 in the ACC. Their conference wins have come against North Carolina State, and last week against California. The Hokies needed double overtime, but they eventually walked away with the win 42-34. Virginia Tech dominated the rushing game against California with a 357 to 39 yard advantage.

Louisville has never beaten Virginia Tech at Lane Stadium, but they are certainly equipped to break that streak this Saturday. But with any streak-breaking game, I don’t think that it will come easy. Virginia Tech fired their head coach Brent Pry earlier this season after an 0-3 start. With offensive coordinator Philip Montgomery stepping in as the interim head coach, the Hokies have shown progression and won three of their last five games. Their defense has been their weakness against high-powered offenses, but they have shown improvement, especially on their home field. While Louisville has been great this season, I wouldn’t consider their offense high-powered or explosive. Quarterback Miller Moss has been efficient this season, throwing for 1793 yards and 10 touchdowns. He will be matched up against Virginia Tech’s quarterback, Kyron Drones. Drones is a dual threat quarterback who can extend plays with his legs. He has thrown for 1516 yards and 14 touchdowns this season. After wins against Miami and Boston College, Louisville is due for a challenge. Louisville will still likely win this game, but I don’t think it comes easy in Lane Stadium.

Virginia Tech +10.5 is available at the time of publishing. Playable at that number.