Michigan State Spartans vs Minnesota Golden Gophers Prediction, Odds and Picks for Today, 11/01/25

The Michigan State Spartans are currently winless in the Big 10 with a conference record of 0-5. The Spartans will try to break that streak this weekend when they travel to Minnesota and battle against the Golden Gophers after going through a brutal conference gauntlet. In order, their losses have come at USC, at Nebraska, at home versus UCLA, at Indiana, and at home against Michigan. The only game in which the Spartans were favored over this run was against UCLA. Quarterback Aidan Chiles went down with an injury in that game, and Michigan State lost 38-13.

Minnesota lost its last game in Iowa 41-3. The Golden Gophers have a conference record of 3-2, but their 2 losses have come by nearly 40 points. Minnesota requires its running game to be productive if it wants to compete. In the 2 conference losses, the Golden Gophers only ran for an average of 19 yards.

This game feels like it is now or never for the Spartans to pick up their first conference win. Remaining conference games on the schedule include Penn State, Iowa, and Maryland for the Spartans. While Michigan State has lost all 5 games by double digits, the Spartans have remained competitive, and they made those games interesting at times. Chiles has thrown for 1392 yards and 10 touchdowns this season. He has all the tools to compete with the Gophers defense. The problem with Michigan State has been its consistency. Quarterback and offensive line play has shown glimpses of positivity, but they have not been able to compete for a full 60 minutes.

Against a team that works as slow as Minnesota, if Michigan State can attack the Gophers corners early, it may open up holes for its running backs later on. The game plan will be clear for Michigan State. If the Spartans can limit the Gophers mediocre running game, they should be able to control time of possession and get their first conference win against a Gophers team that might not be as good as their record entails.

Michigan State vs Minnesota prediction: Michigan State Spartans +3 is available at the time of publishing. Playable at that number.

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