Minnesota Golden Gophers vs Northwestern Wildcats Prediction, Odds and Picks for Saturday, 11/22/25

The Minnesota Golden Gophers will travel this Saturday to take on the Northwestern Wildcats in a Big 10 matchup. The Gophers have a record of 6-4, but all four losses have come on the road. They will try to get their first road win of the season against Northwestern. Minnesota’s last loss came at the hands of Oregon 42-13. Quarterback Drake Lindsey threw for 138 yards and 1 touchdown, but the Gophers defense allowed a recently struggling Oregon offense to explode for 42 points. Like Oregon, Northwestern will be looking to turn around their recent struggles. The Wildcats have lost their last three games, including their last loss 24-22 against Michigan. Northwestern led this game late, but they could not hold on as Michigan took the lead on a late field goal. Northwestern’s defense did force two interceptions, and will be looking to create more turnovers this week against Minnesota.

This should be a good opportunity where Northwestern’s defense can carry them to victory. Northwestern’s defense has been their strength all season, ranking in the top half of the FBS in yards and points allowed per game. They flexed their muscles against Michigan, but came up just short. Now they get a second chance on their home field against a Minnesota team that has really struggled away from home. The Gophers have only averaged 8.3 points per game when playing on the road this season. Against Oregon, they were able to break an 11-quarter drought where their offense was left without a touchdown. The defense has also been Minnesota’s strength, but they have also shown inconsistencies on the road, allowing over 40 points scored in all of their last three road games. Quarterback Preston Stone has seemingly done just enough all season, and he should have the opportunity to get enough things done against a Gophers defense that ranks 64th against the pass. I like for Northwestern to break their losing streak against a Minnesota team that has not shown any life away from their home field.

Northwestern -3.5 is available at the time of publishing. Playable at that number.