Missouri Tigers vs Auburn Tigers Prediction, Odds and Picks for Tomorrow, 10/18/25

We’ve got the Tigers v Tigers in an interesting spot for both Missouri and Auburn. For starters, Mizzou has yet to play a single road game this season with a relatively easy schedule prior to the Alabama matchup, its lone loss. For Auburn, the hosting Tigers are set to face off against a ranked opponent for the fourth-consecutive week, losing the previous matchups by 10 points or less. Auburn has had one of the most difficult schedules in the country through six weeks and have been battle tested while Mizzou’s toughest opponent was a 3-3 South Carolina squad, a matchup it failed to cover the spread in.

Narratives aside, the Auburn defense has been solid all year, even through the gauntlet of a schedule. The hosts rank 29th in yards per game allowed, 18th in defensive success rate and have been particularly excellent against the run, ranking 3rd in EPA/rush, something that should serve well matched up against an elite RB like Ahmad Hardy. On the other side of the ball, the run game has been solid for Auburn, ranking 15th in EPA/rush, while QB Jackson Arnold has taken care of the ball with 0 INTs through six games. This is a tough place to win on the road, I’ve got Auburn covering at home.

Missouri vs Auburn prediction: Auburn +1.5 (-110) available at time of publishing. Playable at that number or better.