Missouri Tigers vs Auburn Tigers Prediction, Odds and Picks for Today, 10/18/25

We’ve got the Tigers vs Tigers in an interesting spot for both Missouri and Auburn. For starters, Mizzou has yet to play a single road game this season and has had a relatively easy schedule prior to the Alabama matchup – its lone loss. For Auburn, the hosting Tigers are set to face-off against a ranked opponent for the 4h-consecutive week, losing the previous matchups by 10 points or less. Auburn has had one of the most difficult schedules in the country through 6 weeks and has been battle tested, while Mizzou’s toughest opponent outside of Bama was a 3-3 South Carolina squad – a matchup in which the Tigers failed to cover the spread.

Narratives aside, the Auburn defense has been solid all year, even through the gauntlet of a schedule. The hosts rank 29th in yards per game allowed, 18th in defensive success rate and have been particularly excellent against the run, ranking 3rd in EPA/rush – something that should serve well matched-up against an elite RB like Ahmad Hardy. On the other side of the ball, the run game has been solid for Auburn, ranking 15th in EPA/rush, while QB Jackson Arnold has taken care of the ball with 0 INTs through 6 games. This is a tough place to win on the road, I’ve got Auburn covering at home.

Missouri vs Auburn prediction: Auburn Tigers +1.5 (-110) available at time of publishing. Playable at that number or better.

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