NC State Wolfpack vs Pittsburgh Panthers Prediction, Odds and Picks for Saturday, 10/25/25
NC State vs Pittsburgh Pickswise Expert Predictions
The Pittsburgh Panthers have been rolling ever since making a switch at QB following back-to-back losses with Mason Heintschel taking over for Eli Holstein and leading the Panthers to three straight wins with an average win-margin of 20.3 PPG throughout that stretch including an upset win on the road over Florida State. The real star of the show for PITT, however, has been the defense. Pittsburgh ranks 4th in FBS in rushing defense — allowing only 82.4 yards per game on the ground — and 12th in EPA/rush allowed.
The Wolfpack likes to run the ball, though they rank 82nd in rushing success rate and will likely have to rely on QB CJ Bailey. The sophomore QB is solid, but he’s somewhat turnover prone and matches up against a Panthers defense that ranks 28th in turnovers gained. Pittsburgh has some mojo rolling right now, and I’m riding the wave and backing the Panthers to cover at home in this spot.
NC State vs Pittsburgh prediction: Pittsburgh -6.5 (-110) available at time of publishing. Playable at that number or better.
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